DIACEREIN+GLUCOSAMINE: Uses, Side Effects and Medicines (2023)

FAQs

What are the side effects of diacerein glucosamine sulphate? ›

Side effects such as Nausea, Diarrhoea, abdominal pain, and indigestion may occur with Diacerein + Glucosamine Sulfate Potassium Chloride + Methyl Sulfonyl Methane. These may not be with everyone. Any of the side effects other than those mentioned above if occur, do consult the treating physician.

Diarrhoea. Diacerein may cause diarrhoea or loose stools in the first few days of treatment.

Diacerein must not be used in any patient with liver disease or a history of liver disease. Doctors should be monitoring their patients for early signs of liver problems and advising them how to recognise early symptoms.

Drug Warnings

DIACEREIN is not recommended for children below 15 years of age and it should be used with caution in elderly patients above 65 years of age. Avoid taking DIACEREIN if you are pregnant or breastfeeding and consult a doctor before taking DIACEREIN.

In conclusion, among patients with type 2 DM and CKD, diacerein does not have an effect on ACR or GFR, but slows metabolic control deterioration and is associated with lower nighttime systolic and diastolic blood pressure.

Drug Warnings

Although it is generally a safe medicine to use, it should be avoided in patients with liver and kidney disease as the DIACEREIN+GLUCOSAMINE may harm the liver and renal functions. Use with caution in pregnancy and breastfeeding.

Adult: Usual dose: 50 mg bid. Alternatively, 50 mg once daily with evening meal for 2-4 weeks. Dose may be increased to 100 mg daily in divided doses according to patient tolerability. Treatment duration may vary according to patient response and expected clinical outcome.

Diacerein (diacerhein or diacetylrhein) is an anthraquinone found in herbal remedies such as yellow dock (Rumex crispus), a common weed resembling rhubarb. Yellow dock root has been used historically as a cathartic, but was also recommended for arthritis.

Taking glucosamine sulfate and acetaminophen together might reduce the effectiveness of both the supplement and medication. Warfarin (Jantoven). Taking glucosamine alone or in combination with the supplement chondroitin might increase the effects of the anticoagulant warfarin. This can increase your risk of bleeding.

Who Cannot take glucosamine? ›

Glucosamine may also increase glaucoma risk. Therefore, it shouldn't be taken by those at risk of developing glaucoma, including those with a family history of glaucoma, people ages 60 or older, and those who have diabetes, heart disease, or high blood pressure ( 31 ).

Diacerein (DCN) was obtained by diacetylation of an anthraquinone derivative rhein and was approved by FDA in 2008, in the treatment of osteoarthritis due to its inhibitory effect on proinflammatory cytokines, including IL-6 and IL-1β.

Glucosamine and chondroitin are two of the most commonly used supplements for arthritis. They're components of cartilage—the substance that cushions the joints.

In some statistics, people who take glucosamine for more than 2 years experience acute interstitial nephritis as a side effect. There are also patients with nonspecific signs of renal failure and high levels of renal and hepatic toxicity, who have had a long history of glucosamine-related products.

High blood pressure: There used to be some concern that glucosamine might increase blood pressure. But most research shows that glucosamine does not seem to increase blood pressure.

Methotrexate is widely regarded as one of the safest of all arthritis drugs, though it carries some potential downsides. Gastrointestinal symptoms such as nausea and vomiting are its most frequent side effects.

The drug is not available in the United States, the European Union, Canada, Britain, or Australia.

The results of these investigations suggest that diacerein may be better than glucosamine for reducing pain, but both have similar efficacy for improving joint function.

Diacerein (INN), also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis (swelling and pain in the joints). It works by inhibiting interleukin-1 beta.

DIACEREIN+GLUCOSAMINE+METHYLSULFONYLMETHANE belongs to a group of medications known as 'supplements & adjuvant therapy' used to reduce the pain of osteoarthritis (OA) in specific large and small joints.

What is diacerein 50mg and glucosamine 500mg used for? ›

Diacerein + Glucosamine is a combination of two medicines: Diacerein and Glucosamine, which relieves osteoarthritis symptoms. It helps in the formation of cartilage (the soft tissue that cushions the joints) and keep the joints lubricated for better movement and flexibility.

Based on in vivo and in vitro experiments in animals and humans, diacerein may be responsible for insulin resistance and glycemic control improvement due to the decrease of some cytokine concentrations such as IL-6, TNF-α, and specially IL-1 [33-37].

Arthodia-G - Aronex [Diacerein]

Interactions between your drugs

No interactions were found between Glucosamine & Chondroitin with MSM and multivitamin with minerals. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Diacerein may increase the hepatotoxic activities of Acetaminophen. The metabolism of Acetohexamide can be decreased when combined with Diacerein. The metabolism of Acetylsalicylic acid can be decreased when combined with Diacerein. The metabolism of Acyclovir can be decreased when combined with Diacerein.

For inflammatory conditions such as psoriasis, rheumatoid arthritis or Crohn's disease, the dose of methotrexate will vary. This depends on your condition and blood test results. Always follow the instructions from your doctor. For rheumatoid arthritis, the usual starting dose for adults is 7.5mg, taken once a week.

Dietary Sources

There are no major food sources of glucosamine, so you must get it from supplements. Most supplements are made from chitin, the hard outer shells of shrimp, lobsters, and crabs. Other forms of glucosamine are available for people who are allergic to shellfish.

What foods are high in glucosamine? Food sources of glucosamine are few and far between. The only natural food sources are shellfish shells from shrimp, lobster and crabs. It's these shells that are harvested and used to make the synthetic version of glucosamine that goes into the supplements that are made in labs.

Nevertheless, the steady-state is reached by the third administration and the mean elimination half-life is then around 7 to 8 hours.

What joint supplements should I avoid? ›

Doctors recommend against using glucosamine hydrochloride. Omega-3 fatty acids, found in fish oil and other foods, encourage the body to produce chemicals that help control inflammation. This supplement may help ease stiffness caused by inflammation in people with rheumatoid arthritis, but more research is needed.

Conclusion. In summary, collagen and glucosamine are both essential compounds for maintaining healthy joints, bones, and skin. While collagen provides structural support to the body's connective tissues, glucosamine plays a crucial role in the formation of healthy cartilage.

It is OK to take glucosamine every day, but check with your healthcare provider. For example, with osteoarthritis, the following doses have been studied: By mouth: 1,500 milligrams (mg) per day, taken either at once, in two doses of 750 mg, or in three doses of 500 mg.

Glucosamine supplements have also been implicated in chronic liver disease and in worsening underlying asthma. Some patients may also experience digestive symptoms such as heartburn. The risks of other side-effects seem unclear, including whether it raises blood glucose levels in people with or without diabetes.

Although glucosamine is unlikely to raise cholesterol levels in most people and is generally considered safe, keep in mind that, in some people, it can cause an allergic reaction, increase eye pressure, and have an anti-coagulant effect.

Glucosamine should be used with caution in patients with renal impairment; side effects and renal function should be monitored. It is advisable to avoid glucosamine for patients with severe renal impairment and those on dialysis until more data are available.

GLUCOSAMINE+METHYL SULFONYL METHANE+DIACEREIN is used to treat and relieve symptoms of osteoarthritis. GLUCOSAMINE+METHYL SULFONYL METHANE+DIACEREIN works by helping in the build-up of cartilage, a connective tissue located on the bones near the joints. This build-up of cartilage helps in joint repair.

Artrodar side effects

Very common: Diarrhea, abdominal pain. Possible flatulence, increased intestinal motility These effects are common in the first few days of treatment and may decrease with continued use of the drug.

Diacerein was found to be stable under dry heat conditions and also no decomposition was seen on exposure of solid drug powder to light, which was kept in day light for 360 h.

1. Omega-3 fatty acids. Omega-3 fatty acids , which are abundant in fatty fish such as salmon or tuna, are among the most potent anti-inflammatory supplements. These supplements may help fight several types of inflammation, including vascular inflammation.

What is the best joint supplement for older people? ›

Fish oil, SAM-e and curcumin are among the supplements with the best evidence to support them. The research on glucosamine and chondroitin, some of the most popular supplements for osteoarthritis, is mixed, but they may help with OA pain and stiffness.

Studies also have found that a lack of vitamin D is linked to rheumatoid arthritis, an autoimmune disease characterized by swollen, aching joints and numbness and tingling in the hands and feet.

Glucosamine has been implicated in isolated case reports in causing clinically apparent liver injury, but the role of glucosamine as opposed to other herbal components or contaminants has not been shown, and liver injury due to glucosamine or chondroitin must be very rare if it occurs at all.

A high concentration of glucosamine diminishes the level of SIRT1, leading to cell death in the tissues where this protein is abundant, such as the pancreas.

Some glucosamine products also contain manganese. Taking too much of this combination can cause a manganese overdose. Do not take more than directed on the medicine label.

In conclusion, based on the results of this study, glucosamine causes statistically significant rise in IOP, which is more pronounced in elderly patients.

Patients taking blood-thinning medications or daily aspirin should not take chondroitin sulfate, as it may contribute to bleeding. Arthritis Foundation.

People who regularly take glucosamine were found to have a lower risk of coronary heart disease, stroke and death from heart or circulatory diseases, according to a new study.

Taking glucosamine sulfate and acetaminophen together might reduce the effectiveness of both the supplement and medication. Warfarin (Jantoven). Taking glucosamine alone or in combination with the supplement chondroitin might increase the effects of the anticoagulant warfarin. This can increase your risk of bleeding.

Glucosamine should be used with caution in patients with renal impairment; side effects and renal function should be monitored. It is advisable to avoid glucosamine for patients with severe renal impairment and those on dialysis until more data are available.

Who should avoid glucosamine? ›

Glucosamine is likely safe for most people, although mild gastrointestinal upset has been reported in some individuals. Avoid these supplements if you are at risk for glaucoma or if you're pregnant or breastfeeding.

The best time to take your glucosamine supplement is… the same time each day, no matter what time that is. With most glucosamine supplements, it is suggested by some experts that you take it with your meals to support digestive health.

Taking glucosamine may not affect blood glucose levels directly, but some evidence from both animal and human studies suggests that it may promote insulin resistance over time.

Studies suggest that glucosamine is safe and causes only minor side effects, such as stomach upset, heartburn, indigestion, gas, bloating, nausea, and diarrhea. If these occur, try taking glucosamine with food.

Common side effects are nausea, vomiting, abdominal pain, and diarrhea. There is a risk for severe and life-threatening allergic reactions to glucosamine in people with shellfish allergy or those with asthma.

They work together to reduce joint pain and increase joint health. In addition to helping the muscles, they can boost the immune system and reduce the risk of cancer. In a study conducted by the University of California, researchers found that glucosamine and vitamin D can be taken at the same time.