DIACEREIN+GLUCOSAMINE belongs to a class of medications called 'non-steroidal anti-inflammatory (NSAID)/ anti-inflammatory and antirheumatic agents, non-steroids', primarily taken for reducing the pain of osteoarthritis (OA) in specific large and small joints. Osteoarthritis is a chronic (lifelong) joint condition in which Glucosamine sulfate (a chemical found in the human body, especially in joints) gets reduced. The body uses this fluid to produce other chemicals required to make ligaments, cartilage, tendons, and the thick fluid surrounding joints. When this chemical gets reduced, then the cartilage breaks down and becomes thin, which causes friction between the bones leading to wear and tear (damage) of the joint tissues leading to pain, stiffness, inflammation, and reduced locomotion.
The DIACEREIN+GLUCOSAMINE compromises two medicines, namely Diacerein and Glucosamine. Diacerein restricts the action of a protein responsible for causing inflammation and destruction of cartilage or osteoarthritis. At the same time, Glucosamine sulfate is a natural protein found in the body used by the body to produce various chemicals responsible for building ligaments, cartilage, tendons, and the thick fluid surrounding joints. Taking DIACEREIN+GLUCOSAMINE may either enhance the cartilage and fluid surrounding joints or prevent both components' breakdown. In combination, both help form cartilage (the soft tissue that cushions the joints) and make the joints lubricated for better movement and flexibility. DIACEREIN+GLUCOSAMINE relieves pain, thereby improving joint function and helping individuals restore their quality of life. It also increases the cushioning and lubrication of joints that, provide relief in pain and easily do physical activity.
Take DIACEREIN+GLUCOSAMINE as prescribed by your doctor. You are suggested to take DIACEREIN+GLUCOSAMINE as long as your doctor has prescribed it after checking your medical condition. Sometimes, you may experience certain common side effects, such as headache, tiredness, nausea, abdominal pain, indigestion, diarrhoea, constipation, and wind. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these undesirable effects persistently.
DIACEREIN+GLUCOSAMINE is not allowed to be used in children younger than 18. Consult your doctor if you have ever had blood clots or circulation problems in your legs or if you are pregnant or planning to be pregnant, as this may harm an unborn baby. Tell your doctor if you are breastfeeding as It may not be safe to breastfeed a baby while taking DIACEREIN+GLUCOSAMINE. People with joint infection or skin disease in the affected area should consult a doctor before taking DIACEREIN+GLUCOSAMINE. People dealing with impaired glucose tolerance, kidney or liver dysfunction risk factors for heart (cardiovascular) disease, and who have asthma should take DIACEREIN+GLUCOSAMINE with caution.
Uses of GLUCOSAMINE+DIACEREIN
The DIACEREIN+GLUCOSAMINE compromises two medicines, namely Diacerein and Glucosamine. Diacerein restricts the action of a protein responsible for causing inflammation and destruction of cartilage or osteoarthritis. At the same time, Glucosamine sulfate is a natural protein found in the body used by the body to produce a variety of chemicals responsible for building ligaments, cartilage, tendons, and the thick fluid surrounding joints. Taking DIACEREIN+GLUCOSAMINE may either enhance the cartilage and fluid surrounding joints or prevent both components' breakdown. In combination, both help form cartilage (the soft tissue that cushions the joints) and make the joints lubricated for better movement and flexibility. DIACEREIN+GLUCOSAMINE relieves pain, thereby improving joint function and helping individuals restore their quality of life. It also increases the cushioning and lubrication of joints, provides relief from pain and easily do physical activity.
Directions for Use
Swallow it as a whole with water; do not crush, break or chew it.
Store in a cool and dry place away from sunlight
Side Effects of GLUCOSAMINE+DIACEREIN
- Abdominal pain
- Wind (flatulence)
In-Depth Precautions and Warning
Consumption of alcohol should be avoided during the treatment with DIACEREIN+GLUCOSAMINE as it may lead to an increased risk of liver damage. Patients with blood clots or leg circulation problems should not take DIACEREIN+GLUCOSAMINE. Although it is generally a safe medicine to use, it should be avoided in patients with liver and kidney disease as the DIACEREIN+GLUCOSAMINE may harm the liver and renal functions. Use with caution in pregnancy and breastfeeding. Do not self-administer DIACEREIN+GLUCOSAMINE if you are pregnant or are nursing. Although DIACEREIN+GLUCOSAMINE provides symptomatic relief in conditions like arthritis and may reduce the inflammation caused by these conditions, it is strongly recommended to remain physically active as much as your condition allows to achieve the best results. Adopting a healthy lifestyle and a diet containing high proteins is the mainstay for managing arthritic conditions.
Drug-Drug Interactions:DIACEREIN+GLUCOSAMINE can interact with medicines used for blood thinning (Warfarin), Medications for cancer (Paclitaxel), painkillers (Acetaminophen), Antidiabetes drugs (glimepiride, pioglitazone). Inform your doctor if you are using any of these.
Drug-Food Interactions: Avoid intake of Vitamin E, St. John’s wort (antidepressant), and Ginkgo Biloba with DIACEREIN+GLUCOSAMINE.
Drug-Disease Interactions: People dealing with impaired glucose tolerance, kidney or liver dysfunction risk factor for heart (cardiovascular) disease, and suffering from asthma should take DIACEREIN+GLUCOSAMINE with caution.
Drug-Drug Interactions Checker List:
You are recommended not to consume alcohol along with DIACEREIN+GLUCOSAMINE to avoid unpleasant side effects.
DIACEREIN+GLUCOSAMINE should not be injected in pregnancy as the safety and effectiveness of DIACEREIN+GLUCOSAMINE has not been established. Please consult your doctor.
DIACEREIN+GLUCOSAMINE should not be injected in breastfeeding mothers as the safety and effectiveness of DIACEREIN+GLUCOSAMINE have not been established.
caution(Video) Glucosamine For Joints | Glucosamine Sulphate Tablets Benefits,Uses,Dose & Side Effects In Hindi
In some cases, DIACEREIN+GLUCOSAMINE may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
DIACEREIN+GLUCOSAMINE should be used with caution in persons dealing with any liver disorders. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
DIACEREIN+GLUCOSAMINE should be used with caution in persons dealing with kidney disorders. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.
DIACEREIN+GLUCOSAMINE can not be given to persons younger than 18 years of age as the safety and effectiveness of DIACEREIN+GLUCOSAMINE have not been established.
Diet & Lifestyle Advise
- Include more glucosamine, chondroitin sulfate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
- Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.
- Including fish like salmon, trout, tuna, and sardines in your daily diet. These fishes are enriched with omega-3 fatty acids with a minimum level of chemicals called cytokines, which ramp up inflammation.
- Your sitting posture is important, especially when you have pain and inflammation condition. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel to minimise pain at the back of your curve. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.
- X- rays of affected joints is done to identify osteoarthritis
Pain: Pain is an unpleasant and emotional experience associated with tissue damage. It allows the body to react and prevent further tissue damage. Pain can be short-term (acute) or long-term (chronic). Pain perception can differ from person to person, from tolerable to non-tolerable.
Osteoarthritis:Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation and tenderness. The main reason for osteoarthritis is age; the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include past injuries such as torn cartilage, and dislocated joints and ligaments.
Who is not allowed to take DIACEREIN+GLUCOSAMINE?
DIACEREIN+GLUCOSAMINE is not suggested in patients having liver problems. DIACEREIN+GLUCOSAMINE is also not administered to patients with known allergies to DIACEREIN+GLUCOSAMINE.
Can DIACEREIN+GLUCOSAMINE be used in joints other than knee?
The safety and effectiveness of DIACEREIN+GLUCOSAMINE in joints other than the knee have not been established. So its use in parts other than the knee joint should be avoided.
What is Glucosamine?
Glucosamine sulfate is a natural protein found in the body used by the body to produce a variety of chemicals responsible for building ligaments, cartilage, tendons, and the thick fluid surrounding joints. Taking DIACEREIN+GLUCOSAMINE may either enhance the cartilage and fluid surrounding joints or prevent both components' breakdown.
What should I tell my doctor before taking DIACEREIN+GLUCOSAMINE?
You are advised to tell your doctor if you have diabetes, high cholesterol or triglycerides (a type of fat in the blood), cancer, liver disease, asthma, or other breathing disorder if you are allergic to shellfish, or you have taken a blood thinner (warfarin, Coumadin, Jantoven).
Should I go for regular checkups of sugar while taking DIACEREIN+GLUCOSAMINE?
Some research suggests that the presence of Glucosamine in DIACEREIN+GLUCOSAMINE may affect antidiabetic drugs; it can also increase the sugar level in the blood in type 2 diabetes. This is why it is suggested to go for regular checkups of blood sugar with type 2 diabetes.
I am already taking blood-thinning medicines, such as warfarin, should I tell it to my doctor?
DIACEREIN+GLUCOSAMINE may increase the risk of bleeding in people taking Warfarin, so it is advised to tell your doctor if you are taking Warfarin or any other medicine.
I have ongoing medical conditon that is "high blood pressure" should I tell it to doctor before taking DIACEREIN+GLUCOSAMINE?
Some research suggests that glucosamine sulfate may enhance insulin levels in the body which can increase blood pressure. To be safer side, go for regular blood checks and closely monitor your blood pressure.
I have shellfish allergy, can I take DIACEREIN+GLUCOSAMINE?
It has been noticed that DIACEREIN+GLUCOSAMINE may cause allergic reactions in persons who are sensitive to shellfish. Glucosamine is produced synthetically from shells of shrimp, lobster, and crabs.
I have glaucoma should I tell it to my doctor?
Some research suggests that DIACEREIN+GLUCOSAMINE may increase pressure inside the eye and may worsen glaucoma. So if you have glaucoma then tell to your doctor.
Side effects such as Nausea, Diarrhoea, abdominal pain, and indigestion may occur with Diacerein + Glucosamine Sulfate Potassium Chloride + Methyl Sulfonyl Methane. These may not be with everyone. Any of the side effects other than those mentioned above if occur, do consult the treating physician.What are the disadvantages of diacerein? ›
Diarrhoea. Diacerein may cause diarrhoea or loose stools in the first few days of treatment.Who should not take diacerein? ›
Diacerein must not be used in any patient with liver disease or a history of liver disease. Doctors should be monitoring their patients for early signs of liver problems and advising them how to recognise early symptoms.Does glucosamine have negative side effects? ›
DIACEREIN is not recommended for children below 15 years of age and it should be used with caution in elderly patients above 65 years of age. Avoid taking DIACEREIN if you are pregnant or breastfeeding and consult a doctor before taking DIACEREIN.
In conclusion, among patients with type 2 DM and CKD, diacerein does not have an effect on ACR or GFR, but slows metabolic control deterioration and is associated with lower nighttime systolic and diastolic blood pressure.Is diacerein safe for kidneys? ›
Although it is generally a safe medicine to use, it should be avoided in patients with liver and kidney disease as the DIACEREIN+GLUCOSAMINE may harm the liver and renal functions. Use with caution in pregnancy and breastfeeding.
Adult: Usual dose: 50 mg bid. Alternatively, 50 mg once daily with evening meal for 2-4 weeks. Dose may be increased to 100 mg daily in divided doses according to patient tolerability. Treatment duration may vary according to patient response and expected clinical outcome.What is the natural source of diacerein? ›
Diacerein (diacerhein or diacetylrhein) is an anthraquinone found in herbal remedies such as yellow dock (Rumex crispus), a common weed resembling rhubarb. Yellow dock root has been used historically as a cathartic, but was also recommended for arthritis.What medications Cannot be taken with glucosamine? ›
Taking glucosamine sulfate and acetaminophen together might reduce the effectiveness of both the supplement and medication. Warfarin (Jantoven). Taking glucosamine alone or in combination with the supplement chondroitin might increase the effects of the anticoagulant warfarin. This can increase your risk of bleeding.
Glucosamine may also increase glaucoma risk. Therefore, it shouldn't be taken by those at risk of developing glaucoma, including those with a family history of glaucoma, people ages 60 or older, and those who have diabetes, heart disease, or high blood pressure ( 31 ).Is diacerein FDA approved? ›
Diacerein (DCN) was obtained by diacetylation of an anthraquinone derivative rhein and was approved by FDA in 2008, in the treatment of osteoarthritis due to its inhibitory effect on proinflammatory cytokines, including IL-6 and IL-1β.What is the best joint supplement for arthritis? ›
Glucosamine and chondroitin are two of the most commonly used supplements for arthritis. They're components of cartilage—the substance that cushions the joints.Does glucosamine affect kidneys? ›
In some statistics, people who take glucosamine for more than 2 years experience acute interstitial nephritis as a side effect. There are also patients with nonspecific signs of renal failure and high levels of renal and hepatic toxicity, who have had a long history of glucosamine-related products.Does glucosamine raise blood pressure? ›
High blood pressure: There used to be some concern that glucosamine might increase blood pressure. But most research shows that glucosamine does not seem to increase blood pressure.What is the safest drug for arthritis? ›
Methotrexate is widely regarded as one of the safest of all arthritis drugs, though it carries some potential downsides. Gastrointestinal symptoms such as nausea and vomiting are its most frequent side effects.Is diacerein available in USA? ›
The drug is not available in the United States, the European Union, Canada, Britain, or Australia.Is diacerein and glucosamine same? ›
The results of these investigations suggest that diacerein may be better than glucosamine for reducing pain, but both have similar efficacy for improving joint function.What are the benefits of diacerein? ›
Diacerein (INN), also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis (swelling and pain in the joints). It works by inhibiting interleukin-1 beta.What class of drug is diacerein glucosamine? ›
DIACEREIN+GLUCOSAMINE+METHYLSULFONYLMETHANE belongs to a group of medications known as 'supplements & adjuvant therapy' used to reduce the pain of osteoarthritis (OA) in specific large and small joints.
Diacerein + Glucosamine is a combination of two medicines: Diacerein and Glucosamine, which relieves osteoarthritis symptoms. It helps in the formation of cartilage (the soft tissue that cushions the joints) and keep the joints lubricated for better movement and flexibility.Is diacerein safe in diabetes? ›
Based on in vivo and in vitro experiments in animals and humans, diacerein may be responsible for insulin resistance and glycemic control improvement due to the decrease of some cytokine concentrations such as IL-6, TNF-α, and specially IL-1 [33-37].What is the brand name for diacerein? ›
Arthodia-G - Aronex [Diacerein]Can I take glucosamine with other vitamins? ›
Interactions between your drugs
No interactions were found between Glucosamine & Chondroitin with MSM and multivitamin with minerals. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
|Composition||Diacerein 50 Mg +Glucosamine Sulfate Potassium 750 Mg + Methyl Sulphonyl Methane 250 Mg|
Diacerein may increase the hepatotoxic activities of Acetaminophen. The metabolism of Acetohexamide can be decreased when combined with Diacerein. The metabolism of Acetylsalicylic acid can be decreased when combined with Diacerein. The metabolism of Acyclovir can be decreased when combined with Diacerein.What is the once a week Tablet for arthritis? ›
For inflammatory conditions such as psoriasis, rheumatoid arthritis or Crohn's disease, the dose of methotrexate will vary. This depends on your condition and blood test results. Always follow the instructions from your doctor. For rheumatoid arthritis, the usual starting dose for adults is 7.5mg, taken once a week.How can I get glucosamine naturally? ›
There are no major food sources of glucosamine, so you must get it from supplements. Most supplements are made from chitin, the hard outer shells of shrimp, lobsters, and crabs. Other forms of glucosamine are available for people who are allergic to shellfish.
What foods are high in glucosamine? Food sources of glucosamine are few and far between. The only natural food sources are shellfish shells from shrimp, lobster and crabs. It's these shells that are harvested and used to make the synthetic version of glucosamine that goes into the supplements that are made in labs.What is the half life of diacerein? ›
Nevertheless, the steady-state is reached by the third administration and the mean elimination half-life is then around 7 to 8 hours.
Doctors recommend against using glucosamine hydrochloride. Omega-3 fatty acids, found in fish oil and other foods, encourage the body to produce chemicals that help control inflammation. This supplement may help ease stiffness caused by inflammation in people with rheumatoid arthritis, but more research is needed.Which is better for arthritis collagen or glucosamine? ›
Conclusion. In summary, collagen and glucosamine are both essential compounds for maintaining healthy joints, bones, and skin. While collagen provides structural support to the body's connective tissues, glucosamine plays a crucial role in the formation of healthy cartilage.Is it OK to take glucosamine everyday? ›
It is OK to take glucosamine every day, but check with your healthcare provider. For example, with osteoarthritis, the following doses have been studied: By mouth: 1,500 milligrams (mg) per day, taken either at once, in two doses of 750 mg, or in three doses of 500 mg.Why should I stop taking glucosamine? ›
Glucosamine supplements have also been implicated in chronic liver disease and in worsening underlying asthma. Some patients may also experience digestive symptoms such as heartburn. The risks of other side-effects seem unclear, including whether it raises blood glucose levels in people with or without diabetes.Does glucosamine raise cholesterol? ›
Although glucosamine is unlikely to raise cholesterol levels in most people and is generally considered safe, keep in mind that, in some people, it can cause an allergic reaction, increase eye pressure, and have an anti-coagulant effect.Is glucosamine hard on kidney? ›
Glucosamine should be used with caution in patients with renal impairment; side effects and renal function should be monitored. It is advisable to avoid glucosamine for patients with severe renal impairment and those on dialysis until more data are available.What is diacerein glucosamine MSM tablets for? ›
GLUCOSAMINE+METHYL SULFONYL METHANE+DIACEREIN is used to treat and relieve symptoms of osteoarthritis. GLUCOSAMINE+METHYL SULFONYL METHANE+DIACEREIN works by helping in the build-up of cartilage, a connective tissue located on the bones near the joints. This build-up of cartilage helps in joint repair.What is the side effect of Artrodar diacerein? ›
Artrodar side effects
Very common: Diarrhea, abdominal pain. Possible flatulence, increased intestinal motility These effects are common in the first few days of treatment and may decrease with continued use of the drug.
Diacerein was found to be stable under dry heat conditions and also no decomposition was seen on exposure of solid drug powder to light, which was kept in day light for 360 h.What is the strongest natural anti-inflammatory? ›
1. Omega-3 fatty acids. Omega-3 fatty acids , which are abundant in fatty fish such as salmon or tuna, are among the most potent anti-inflammatory supplements. These supplements may help fight several types of inflammation, including vascular inflammation.
Fish oil, SAM-e and curcumin are among the supplements with the best evidence to support them. The research on glucosamine and chondroitin, some of the most popular supplements for osteoarthritis, is mixed, but they may help with OA pain and stiffness.What vitamin deficiency causes arthritis? ›
Studies also have found that a lack of vitamin D is linked to rheumatoid arthritis, an autoimmune disease characterized by swollen, aching joints and numbness and tingling in the hands and feet.Is glucosamine hard on the liver? ›
Glucosamine has been implicated in isolated case reports in causing clinically apparent liver injury, but the role of glucosamine as opposed to other herbal components or contaminants has not been shown, and liver injury due to glucosamine or chondroitin must be very rare if it occurs at all.Does glucosamine affect pancreas? ›
A high concentration of glucosamine diminishes the level of SIRT1, leading to cell death in the tissues where this protein is abundant, such as the pancreas.Can too much glucosamine be harmful? ›
Some glucosamine products also contain manganese. Taking too much of this combination can cause a manganese overdose. Do not take more than directed on the medicine label.Does glucosamine affect eye pressure? ›
In conclusion, based on the results of this study, glucosamine causes statistically significant rise in IOP, which is more pronounced in elderly patients.Who should not take glucosamine & chondroitin? ›
Patients taking blood-thinning medications or daily aspirin should not take chondroitin sulfate, as it may contribute to bleeding. Arthritis Foundation.Is glucosamine good for your heart? ›
People who regularly take glucosamine were found to have a lower risk of coronary heart disease, stroke and death from heart or circulatory diseases, according to a new study.What to avoid when taking glucosamine? ›
Taking glucosamine sulfate and acetaminophen together might reduce the effectiveness of both the supplement and medication. Warfarin (Jantoven). Taking glucosamine alone or in combination with the supplement chondroitin might increase the effects of the anticoagulant warfarin. This can increase your risk of bleeding.Is glucosamine sulfate hard on kidneys? ›
Glucosamine should be used with caution in patients with renal impairment; side effects and renal function should be monitored. It is advisable to avoid glucosamine for patients with severe renal impairment and those on dialysis until more data are available.
Glucosamine is likely safe for most people, although mild gastrointestinal upset has been reported in some individuals. Avoid these supplements if you are at risk for glaucoma or if you're pregnant or breastfeeding.Is it better to take glucosamine in the morning or at night? ›
The best time to take your glucosamine supplement is… the same time each day, no matter what time that is. With most glucosamine supplements, it is suggested by some experts that you take it with your meals to support digestive health.Does glucosamine raise blood sugar? ›
Taking glucosamine may not affect blood glucose levels directly, but some evidence from both animal and human studies suggests that it may promote insulin resistance over time.Does glucosamine affect bowels? ›
Studies suggest that glucosamine is safe and causes only minor side effects, such as stomach upset, heartburn, indigestion, gas, bloating, nausea, and diarrhea. If these occur, try taking glucosamine with food.What are the signs of glucosamine toxicity? ›
Common side effects are nausea, vomiting, abdominal pain, and diarrhea. There is a risk for severe and life-threatening allergic reactions to glucosamine in people with shellfish allergy or those with asthma.What are the negative side effects of glucosamine chondroitin? ›
- nausea, diarrhea, constipation;
- stomach pain, gas, bloating;
- hair loss; or.
- puffy eyelids.
They work together to reduce joint pain and increase joint health. In addition to helping the muscles, they can boost the immune system and reduce the risk of cancer. In a study conducted by the University of California, researchers found that glucosamine and vitamin D can be taken at the same time.