Overview
Location [1]
12q14.1
Pathway
Cell cycle control
Protein [2]
Cyclin-dependent kinase 4
Synonyms [1]
CMM3, PSK-J3
Cyclin-dependent kinase 4 (CDK4) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the progression of the cell cycle at from G1 to S phase and the activation of RB1. Missense and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
CDK4 is altered in 2.17% of all cancers with lung adenocarcinoma, dedifferentiated liposarcoma, conventional glioblastoma multiforme, glioblastoma, and well differentiated liposarcoma having the greatest prevalence of alterations [3].
CDK4 GENIE Cases - Top Diseases
The most common alterations in CDK4 are CDK4 Amplification (1.95%), CDK4 Mutation (0.41%), CDK4 Fusion (0.08%), CDK4 R24L (0.04%), and CDK4 Loss (0.03%) [3].
CDK4 GENIE Cases - Top Alterations
Significance of CDK4 in Diseases
Liposarcoma +
Malignant Solid Tumor +
Breast Carcinoma +
Malignant Glioma +
Melanoma +
Soft Tissue Sarcoma +
Colorectal Carcinoma +
Osteosarcoma +
Non-Small Cell Lung Carcinoma +
Head And Neck Squamous Cell Carcinoma +
Ovarian Carcinoma +
Non-Hodgkin Lymphoma +
Acral Lentiginous Melanoma +
Glioblastoma +
Mucosal Melanoma +
Primary Peritoneal Carcinoma +
Gallbladder Carcinoma +
Lung Adenocarcinoma +
Lung Carcinoma +
Chondrosarcoma +
Adenocarcinoma Of The Gastroesophageal Junction +
Fallopian Tube Carcinoma +
Leiomyosarcoma +
Cancer +
Endometrial Endometrioid Adenocarcinoma +
Gastric Adenocarcinoma +
Gastric Carcinoma +
Malignant Uterine Neoplasm +
Squamous Cell Lung Carcinoma +
Esophageal Carcinoma +
Pancreatic Carcinoma +
Bladder Carcinoma +
Germ Cell Tumor +
Head And Neck Carcinoma +
Multiple Myeloma +
Histiocytic And Dendritic Cell Neoplasm +
Bile Duct Carcinoma +
Ovarian Epithelial Tumor +
Cervical Carcinoma +
Prostate Carcinoma +
B-Cell Non-Hodgkin Lymphoma +
Bronchogenic Carcinoma +
Chordoma +
Dedifferentiated Chondrosarcoma +
Esophageal Squamous Cell Carcinoma +
Meningioma +
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge.Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.
